Mod GRF 1-29
Mod GRF 1-29 (Modified GRF 1-29, also called CJC-1295 without DAC or Tetrasubstituted GRF 1-29) is a modified growth hormone-releasing hormone analog with improved stability over natural GHRH.
Mechanism of Action
Binds to GHRH receptors in the pituitary gland to stimulate growth hormone release. Four amino acid substitutions improve resistance to enzymatic degradation while maintaining biological activity.
Dosage Overview
Dose Range
100 mcg – 200 mcg
Route
subcutaneous
Frequency
3x daily
Cycle Length
8–12 weeks
Reconstitution
Typical Dosage (Research)
Typical dosing: 100-300mcg administered 2-3 times daily, usually combined with a GHRP like Ipamorelin for synergistic effects.
Subcutaneous injection. Best administered on empty stomach. Short half-life (~30 minutes) necessitates multiple daily doses, unlike DAC version.
Considerations for Men & Women
Women: As a GHRH analog, women may experience a more pronounced GH pulse response due to higher baseline GH pulse amplitude. Estrogen status (pre- vs postmenopausal) can affect response magnitude. Often paired with Ipamorelin.
Men: GH response is influenced by testosterone status. Men with low testosterone may have a blunted GH response. Standard dosing protocols apply for both sexes.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 2,500 mcg/ml
Volume to inject: 0.04 ml
Syringe units (U-100): 4.0 units
Pre-filled with Mod GRF 1-29 defaults. Adjust values as needed.
Side Effects & Risks
Flushing, headache, dizziness, and injection site reactions. Generally well-tolerated. May cause water retention.
Not FDA approved. May affect blood glucose. Long-term effects on pituitary function not fully characterized.
Where to Buy Mod GRF 1-29
All Vendor Details →US-based vendor with third-party HPLC testing and published COAs. One of the few reputable sources we've verified for research-grade peptides.
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Who Uses Mod GRF 1-29
Those preferring pulsatile GH release mimicking natural patterns, individuals stacking with GHRPs, anti-aging protocols.
Similar Peptides
View All Alternatives →Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Sermorelin is a synthetic analog of GHRH consisting of the first 29 amino acids of the natural hormone. It was previously FDA-approved for GH deficiency diagnosis and treatment in children.
Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland without significantly affecting cortisol or prolactin.
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue. Unlike peptides, it can be taken orally and has a long half-life, providing 24-hour GH elevation.
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified version of IGF-1 with extended half-life and enhanced potency. The modifications prevent binding to IGF binding proteins, increasing bioavailability.