MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue. Unlike peptides, it can be taken orally and has a long half-life, providing 24-hour GH elevation.

Mechanism of Action

Acts as a potent, selective agonist of the ghrelin receptor (GHS-R1a). Increases GH and IGF-1 levels without affecting cortisol. Mimics ghrelin's GH-releasing effects.

Typical Dosage (Research)

Typical dosing: 10-25mg taken orally once daily. Often taken at night due to sleep benefits and appetite increase.

Oral administration (capsule or liquid). Can be taken with or without food. Long half-life allows once-daily dosing.

Side Effects & Risks

Increased appetite and water retention are most common. May cause lethargy, vivid dreams, and mild numbness. Can affect blood glucose and insulin sensitivity.

May worsen insulin resistance. Not recommended for diabetics without medical supervision. Long-term effects on cancer risk not established.

Who Uses MK-677 (Ibutamoren)

Those seeking oral GH secretagogue, individuals wanting sustained GH elevation, bodybuilders, anti-aging enthusiasts.