IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified version of IGF-1 with extended half-life and enhanced potency. The modifications prevent binding to IGF binding proteins, increasing bioavailability.

Mechanism of Action

Binds to IGF-1 receptors to promote protein synthesis, muscle growth, and fat metabolism. The LR3 modification (13 amino acid extension and arginine substitution) extends half-life from minutes to 20-30 hours.

Typical Dosage (Research)

Research protocols typically use 20-100mcg daily, often divided into multiple injections or administered bilaterally to target muscles.

Intramuscular injection (site-specific growth) or subcutaneous for systemic effects. Often cycled 4-6 weeks on, equal time off.

Side Effects & Risks

Hypoglycemia, joint pain, water retention, potential jaw/hand growth with extended use, and injection site reactions.

May promote growth of existing tumors. Can cause significant hypoglycemia. Long-term effects on insulin sensitivity concerning.

Who Uses IGF-1 LR3

Bodybuilders seeking muscle growth, those in aggressive recovery protocols.