Human Growth Hormone (HGH)
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Mechanism of Action
Binds to GH receptors throughout the body, stimulating IGF-1 production in the liver. Promotes protein synthesis, fat metabolism, and cellular regeneration across multiple tissues.
Dosage Overview
Dose Range
200 mcg – 2 mg
Route
subcutaneous
Frequency
1x daily
Cycle Length
12–24 weeks
Reconstitution
Typical Dosage (Research)
Medical: 0.1-0.3mg/kg/week divided into daily doses. Anti-aging: 1-2 IU daily. Performance: 2-6 IU daily, sometimes higher.
Subcutaneous injection, preferably at night to mimic natural pulsatile release. Rotate injection sites. Store refrigerated.
Considerations for Men & Women
Women: Generally more sensitive to growth hormone, requiring lower doses to achieve equivalent IGF-1 levels. Oral estrogen use increases GH requirements by suppressing hepatic IGF-1 production; transdermal estrogen does not have this effect. GH replacement doses are typically 30-50% lower in women than men for comparable outcomes.
Men: Higher baseline GH clearance rates mean men often need relatively higher doses. Testosterone co-administration may enhance GH effects on body composition. Monitor for interactions with TRT protocols.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 4,000 mcg/ml
Volume to inject: 0.05 ml
Syringe units (U-100): 5.0 units
Pre-filled with Human Growth Hormone (HGH) defaults. Adjust values as needed.
Side Effects & Risks
Joint pain, water retention, carpal tunnel syndrome, potential insulin resistance, and acromegaly features with long-term high doses.
May promote growth of existing tumors. Can cause diabetes with prolonged use. Illegal without prescription. Quality concerns with black market products.
Who Uses Human Growth Hormone (HGH)
Those with diagnosed GH deficiency, anti-aging protocols, athletes and bodybuilders (off-label/prohibited in sports).
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