Sermorelin

Sermorelin is a synthetic analog of GHRH consisting of the first 29 amino acids of the natural hormone. It was previously FDA-approved for GH deficiency diagnosis and treatment in children.

Mechanism of Action

Binds to GHRH receptors in the pituitary gland to stimulate natural GH production and release. Maintains the body's natural feedback mechanisms for GH regulation.

Typical Dosage (Research)

Typical dosing: 200-500mcg administered once daily, usually before bed. Some protocols use twice daily dosing.

Subcutaneous injection, preferably at bedtime to work with natural GH release patterns. Can be combined with GHRPs for synergistic effects.

Side Effects & Risks

Generally well-tolerated. May cause injection site reactions, headache, flushing, or dizziness. Less side effects than direct GH administration.

May not be effective in those with pituitary dysfunction. Long-term effects not fully characterized. Quality varies between sources.

Who Uses Sermorelin

Those seeking a more natural approach to GH enhancement, anti-aging protocols, individuals with age-related GH decline.