KPV

KPV is a tripeptide (Lys-Pro-Val) derived from alpha-melanocyte-stimulating hormone (α-MSH). It retains the potent anti-inflammatory properties of the parent hormone without the tanning or other melanocortin effects.

Mechanism of Action

Inhibits NF-κB activation and reduces inflammatory cytokine production. Enters cells and directly modulates inflammatory signaling without requiring melanocortin receptors.

Typical Dosage (Research)

Oral/sublingual: 200-500mcg 1-3 times daily. Topical formulations for localized inflammation. Also used in enemas for gut inflammation.

Can be taken orally, sublingually, or as suppositories/enemas for gut inflammation. Topical use for skin conditions. Stable orally unlike most peptides.

Side Effects & Risks

Generally very well-tolerated. Minimal systemic effects due to targeted anti-inflammatory action.

Limited clinical research. Mostly used based on extrapolation from α-MSH research. Long-term effects not characterized.

Who Uses KPV

Those with inflammatory conditions, IBD/IBS sufferers, individuals seeking gut health support, those with skin inflammation.