MGF (Mechano Growth Factor)
MGF (Mechano Growth Factor) is a splice variant of IGF-1 that is produced locally in muscle tissue in response to mechanical stress. The non-PEGylated form has a very short half-life.
Mechanism of Action
Activates muscle satellite cells (stem cells) and promotes their proliferation without differentiation, priming them for fusion with existing muscle fibers during repair and growth.
Dosage Overview
Dose Range
400 mcg – 1.2 mg
Route
intramuscular
Frequency
Weekly
Cycle Length
4–6 weeks
Reconstitution
Typical Dosage (Research)
Due to extremely short half-life (minutes), typical protocols use 100-200mcg injected directly into target muscles immediately post-workout.
Intramuscular injection into trained muscles within minutes of workout completion. Must be used immediately after reconstitution due to instability.
Considerations for Men & Women
Women: Similar considerations as PEG-MGF. No established sex-specific differences. Avoid during pregnancy due to growth factor activity.
Men: Used for localized muscle repair. Rapid degradation means timing post-exercise is important. No sex-specific protocols established.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 1,000 mcg/ml
Volume to inject: 0.40 ml
Syringe units (U-100): 40.0 units
Pre-filled with MGF (Mechano Growth Factor) defaults. Adjust values as needed.
Side Effects & Risks
Injection site soreness, potential hypoglycemia, localized swelling. Short half-life limits systemic effects.
Very short half-life makes practical use difficult. Limited research data. PEG-MGF version preferred for practicality.
Who Uses MGF (Mechano Growth Factor)
Researchers, advanced users seeking localized muscle effects, those who can inject immediately post-workout.
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