GHRP-6
Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.
Mechanism of Action
Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.
Dosage Overview
Dose Range
100 mcg – 300 mcg
Route
subcutaneous
Frequency
3x daily
Cycle Length
8–12 weeks
Reconstitution
Typical Dosage (Research)
Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.
Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.
Considerations for Men & Women
Women: Stimulates GH release but also significantly increases ghrelin and hunger — appetite stimulation may be more pronounced in women. May affect prolactin levels slightly. Estrogen status influences GH response.
Men: Appetite stimulation and cortisol elevation are common. The hunger effect is often more tolerable for men in bulking phases. Less selective than Ipamorelin — raises cortisol and prolactin more.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 2,500 mcg/ml
Volume to inject: 0.04 ml
Syringe units (U-100): 4.0 units
Pre-filled with GHRP-6 defaults. Adjust values as needed.
Side Effects & Risks
Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.
May affect blood glucose levels. Increases cortisol and prolactin more than other GHRPs. The hunger effect can be overwhelming for some users.
Where to Buy GHRP-6
All Vendor Details →US-based vendor with third-party HPLC testing and published COAs. One of the few reputable sources we've verified for research-grade peptides.
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Who Uses GHRP-6
Those seeking muscle gain and not concerned about appetite increase, hardgainers, individuals in bulking phases.
Similar Peptides
View All Alternatives →IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified version of IGF-1 with extended half-life and enhanced potency. The modifications prevent binding to IGF binding proteins, increasing bioavailability.
Mod GRF 1-29 (Modified GRF 1-29, also called CJC-1295 without DAC or Tetrasubstituted GRF 1-29) is a modified growth hormone-releasing hormone analog with improved stability over natural GHRH.
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
MGF (Mechano Growth Factor) is a splice variant of IGF-1 that is produced locally in muscle tissue in response to mechanical stress. The non-PEGylated form has a very short half-life.
PEG-MGF (PEGylated Mechano Growth Factor) is a variant of IGF-1 that is produced in response to muscle damage. PEGylation extends its half-life from minutes to several hours, making it practical for use.