GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.

Mechanism of Action

Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.

Typical Dosage (Research)

Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.

Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.

Side Effects & Risks

Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.

May affect blood glucose levels. Increases cortisol and prolactin more than other GHRPs. The hunger effect can be overwhelming for some users.

Who Uses GHRP-6

Those seeking muscle gain and not concerned about appetite increase, hardgainers, individuals in bulking phases.