Semax
Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent.
Mechanism of Action
Enhances BDNF expression, modulates dopamine and serotonin systems, and provides neuroprotective effects. Increases attention, memory formation, and learning.
Dosage Overview
Dose Range
300 mcg – 600 mcg
Route
intranasal
Frequency
2x daily
Cycle Length
2–4 weeks
Reconstitution
Typical Dosage (Research)
Intranasal: 200-600mcg 2-3 times daily. Higher doses (up to 1mg) used in clinical settings for stroke recovery.
Primarily administered intranasally. N-Acetyl Semax Amidate (NASA) is a modified version with enhanced stability and potency.
Considerations for Men & Women
Women: Nootropic and neuroprotective peptide. No established sex-specific differences. Some research suggests women may have slightly different BDNF responses, but clinical significance is unclear.
Men: Same cognitive enhancement profile. Often stacked with Selank for combined anxiolytic and nootropic effects. No sex-specific dosing.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Concentration: 5 mg/ml
Volume to inject: 0.06 ml
Syringe units (U-100): 6.0 units
Pre-filled with Semax defaults. Adjust values as needed.
Side Effects & Risks
Generally well-tolerated. May cause mild irritability or hair shedding in some users.
May affect thyroid function with prolonged use. Limited clinical data outside Russia.
Who Uses Semax
Students, professionals seeking cognitive enhancement, those recovering from brain injury.
Frequently Asked Questions
Similar Peptides
View All Alternatives →Adamax is a modified version of Semax with an adamantane group attached, designed to enhance its nootropic effects and extend duration of action compared to standard Semax.
FGL (FG Loop) is a synthetic peptide that mimics the neural cell adhesion molecule (NCAM) FG loop region. It promotes neuroplasticity and has shown cognitive-enhancing effects in research.
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme found in every living cell. It plays a central role in energy metabolism, DNA repair, gene expression, and cellular signaling. NAD+ levels naturally decline with age, and restoring them has become a major focus of longevity research. Injectable NAD+ bypasses the GI tract for higher bioavailability compared to oral precursors like NMN or NR.
Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.