PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Mechanism of Action
Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways.
Dosage Overview
Dose Range
500 mcg – 2 mg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1–2 weeks
Reconstitution
Typical Dosage (Research)
Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established.
Intranasal administration preferred for CNS delivery. Research compound with limited human use data.
Considerations for Men & Women
Women: Spadin analog targeting TREK-1 channels for antidepressant-like effects. Very limited human data. No established sex-specific differences, though depression prevalence and treatment response can differ by sex.
Men: Same research protocols. Limited clinical data. Short cycling protocols apply equally.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 2,500 mcg/ml
Volume to inject: 0.20 ml
Syringe units (U-100): 20.0 units
Pre-filled with PE-22-28 defaults. Adjust values as needed.
Side Effects & Risks
Very limited human data. Primarily studied in animal models for safety and efficacy.
Highly experimental. Most data from animal studies. Long-term effects completely unknown.
Who Uses PE-22-28
Researchers, advanced biohackers interested in cutting-edge nootropics, those exploring anti-aging cognitive support.
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