MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide that plays a key role in metabolic regulation and has emerged as a significant longevity research target.
Mechanism of Action
Activates AMPK pathway, enhances glucose uptake in skeletal muscle, improves insulin sensitivity, and regulates mitochondrial function. Acts as a metabolic hormone affecting whole-body energy homeostasis.
Dosage Overview
Dose Range
5 mg – 10 mg
Route
subcutaneous
Frequency
Weekly
Cycle Length
8–12 weeks
Reconstitution
Typical Dosage (Research)
Research protocols typically use 5-10mg administered subcutaneously several times per week. Optimal dosing not yet established.
Subcutaneous injection. Often combined with exercise protocols as it enhances exercise capacity and metabolic adaptation.
Considerations for Men & Women
Women: Mitochondrial-derived peptide that improves insulin sensitivity and metabolic function. May be particularly beneficial for women with metabolic syndrome or PCOS-related insulin resistance. No established pregnancy safety data.
Men: Research shows benefits for exercise performance and metabolic health. May improve insulin sensitivity in obese men. No sex-specific dose adjustments.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 5,000 mcg/ml
Volume to inject: 1.00 ml
Syringe units (U-100): 100.0 units
Pre-filled with MOTS-c defaults. Adjust values as needed.
Side Effects & Risks
Limited human data. Animal studies show good tolerability. May affect energy levels and exercise performance.
Research compound with limited human safety data. Long-term effects not characterized. May interact with metabolic medications.
Where to Buy MOTS-c
All Vendor Details →US-based vendor with third-party HPLC testing and published COAs. One of the few reputable sources we've verified for research-grade peptides.
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Finnrick grades are based on independent HPLC lab testing. Learn more · Finnrick is a commercial service — ratings are third-party, not independent.
Who Uses MOTS-c
Longevity researchers, those interested in metabolic optimization, biohackers focused on mitochondrial health.
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