MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide that plays a key role in metabolic regulation and has emerged as a significant longevity research target.
Mechanism of Action
Activates AMPK pathway, enhances glucose uptake in skeletal muscle, improves insulin sensitivity, and regulates mitochondrial function. Acts as a metabolic hormone affecting whole-body energy homeostasis.
Typical Dosage (Research)
Research protocols typically use 5-10mg administered subcutaneously several times per week. Optimal dosing not yet established.
Subcutaneous injection. Often combined with exercise protocols as it enhances exercise capacity and metabolic adaptation.
Side Effects & Risks
Limited human data. Animal studies show good tolerability. May affect energy levels and exercise performance.
Research compound with limited human safety data. Long-term effects not characterized. May interact with metabolic medications.
Who Uses MOTS-c
Longevity researchers, those interested in metabolic optimization, biohackers focused on mitochondrial health.