Argireline
Argireline (Acetyl Hexapeptide-3) is a widely-used cosmetic peptide that reduces wrinkle depth by inhibiting neurotransmitter release. One of the first 'Botox-like' peptides developed for topical use.
Mechanism of Action
Inhibits the formation of the SNARE complex required for neurotransmitter release, reducing the intensity of muscle contractions that cause expression lines.
Typical Dosage (Research)
Topical: 5-10% concentration in serums, applied twice daily. Higher concentrations used in professional treatments.
Topical application to clean skin. Most effective on expression lines (forehead, crow's feet). Consistent use required for visible results.
Side Effects & Risks
Generally very well-tolerated. Occasional mild irritation or dryness. No systemic absorption at cosmetic doses.
Results are modest compared to injectable treatments. Must be used consistently for maintenance. Product quality varies.
Who Uses Argireline
Those seeking to reduce fine lines and wrinkles, individuals wanting needle-free anti-aging options.