Human Growth Hormone (HGH) vs PE-22-28
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Human Growth Hormone (HGH)
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Full details →PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Side-by-Side Comparison
| Aspect | Human Growth Hormone (HGH) | PE-22-28 |
|---|---|---|
| Dose Range | 200 mcg–2 mg | 500 mcg–2 mg |
| Frequency | 1x daily | 1x daily |
| Cycle Length | 12–24 weeks | 1–2 weeks |
| Route | subcutaneous | subcutaneous |
| Mechanism | Binds to GH receptors throughout the body, stimulating IGF-1 production in the liver. Promotes protein synthesis, fat metabolism, and cellular regeneration across multiple tissues. | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. |
| Typical Dosage | Medical: 0.1-0.3mg/kg/week divided into daily doses. Anti-aging: 1-2 IU daily. Performance: 2-6 IU daily, sometimes higher. | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. |
| Administration | Subcutaneous injection, preferably at night to mimic natural pulsatile release. Rotate injection sites. Store refrigerated. | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. |
| Side Effects | Joint pain, water retention, carpal tunnel syndrome, potential insulin resistance, and acromegaly features with long-term high doses. | Very limited human data. Primarily studied in animal models for safety and efficacy. |
| Best For |
What They Have in Common
Human Growth Hormone (HGH), PE-22-28 are both commonly used for:
Key Differences
Unique to Human Growth Hormone (HGH):
Unique to PE-22-28:
Which Has Stronger Evidence?
- Anti-Aging & Longevity: Human Growth Hormone (HGH) has stronger research support.
| Goal | Human Growth Hormone (HGH) | PE-22-28 |
|---|---|---|
| Anti-Aging & Longevity | medium | low |
Key Studies
Human Growth Hormone (HGH)
- Transgenic Artifacts Caused by Passenger Human Growth Hormone.
Trends in endocrinology and metabolism: TEM, 2018
- [Human growth hormone and Turner syndrome].
Anales de pediatria (Barcelona, Spain : 2003), 2017
- Significance of the disulphide bonds of human growth hormone.
Endokrynologia Polska, 2013
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