Humanin vs PE-22-28
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Humanin
Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.
Full details →PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Side-by-Side Comparison
| Aspect | Humanin | PE-22-28 |
|---|---|---|
| Dose Range | 100 mcg–500 mcg | 500 mcg–2 mg |
| Frequency | 1x daily | 1x daily |
| Cycle Length | 4–8 weeks | 1–2 weeks |
| Route | subcutaneous | subcutaneous |
| Mechanism | Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress. | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. |
| Typical Dosage | Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog. | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. |
| Administration | Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities. | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. |
| Side Effects | Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism. | Very limited human data. Primarily studied in animal models for safety and efficacy. |
| Best For |
What They Have in Common
Humanin, PE-22-28 are both commonly used for:
Which Has Stronger Evidence?
- Cognitive Performance: Humanin has stronger research support.
- Anti-Aging & Longevity: Humanin has stronger research support.
| Goal | Humanin | PE-22-28 |
|---|---|---|
| Cognitive Performance | medium | low |
| Anti-Aging & Longevity | medium | low |
Key Studies
Humanin
- Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
Aging cell, 2026
- HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
Cell death & disease, 2025
- The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
European journal of pharmacology, 2025
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