Humanin

Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.

Mechanism of Action

Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.

Typical Dosage (Research)

Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.

Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.

Side Effects & Risks

Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.

Mostly studied in animal models. Long-term human safety not established. May interact with growth factor pathways.

Who Uses Humanin

Longevity researchers, those interested in neuroprotection, biohackers exploring mitochondrial peptides.