Humanin
Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.
Mechanism of Action
Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.
Dosage Overview
Dose Range
100 mcg – 500 mcg
Route
subcutaneous
Frequency
1x daily
Cycle Length
4–8 weeks
Reconstitution
Typical Dosage (Research)
Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.
Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.
Considerations for Men & Women
Women: Mitochondrial-derived peptide with neuroprotective and anti-apoptotic properties. Endogenous humanin levels may differ between sexes. Limited exogenous administration data. Avoid during pregnancy.
Men: Same neuroprotective research interest. Very limited clinical data on exogenous administration for both sexes.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 1,000 mcg/ml
Volume to inject: 0.10 ml
Syringe units (U-100): 10.0 units
Pre-filled with Humanin defaults. Adjust values as needed.
Side Effects & Risks
Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.
Mostly studied in animal models. Long-term human safety not established. May interact with growth factor pathways.
Who Uses Humanin
Longevity researchers, those interested in neuroprotection, biohackers exploring mitochondrial peptides.
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