Humanin vs NA-Selank Amidate
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Humanin
Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.
Full details →NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Side-by-Side Comparison
| Aspect | Humanin | NA-Selank Amidate |
|---|---|---|
| Dose Range | 100 mcg–500 mcg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 4–8 weeks | 2–4 weeks |
| Route | subcutaneous | intranasal |
| Mechanism | Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress. | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. |
| Typical Dosage | Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog. | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. |
| Administration | Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities. | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. |
| Side Effects | Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism. | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. |
| Best For |
What They Have in Common
Humanin, NA-Selank Amidate are both commonly used for:
Key Differences
Unique to Humanin:
Unique to NA-Selank Amidate:
Which Has Stronger Evidence?
| Goal | Humanin | NA-Selank Amidate |
|---|---|---|
| Cognitive Performance | medium | medium |
Key Studies
Humanin
- Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
Aging cell, 2026
- HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
Cell death & disease, 2025
- The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
European journal of pharmacology, 2025
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