GHRP-2 vs GHRP-6 vs Sermorelin

A three-way comparison to help you find the right peptide for your research goals.

GHRP-2

Growth Hormone Releasing Peptide 2 (GHRP-2) is considered one of the most potent GHRPs available. It provides strong GH release with moderate hunger increase compared to GHRP-6.

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GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.

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Sermorelin

Sermorelin is a synthetic analog of GHRH consisting of the first 29 amino acids of the natural hormone. It was previously FDA-approved for GH deficiency diagnosis and treatment in children.

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Side-by-Side Comparison

Aspect	GHRP-2	GHRP-6	Sermorelin
Dose Range	100 mcg–300 mcg	100 mcg–300 mcg	100 mcg–300 mcg
Frequency	3x daily	3x daily	1x daily
Cycle Length	8–12 weeks	8–12 weeks	8–12 weeks
Route	subcutaneous	subcutaneous	subcutaneous
Mechanism	Binds to the ghrelin receptor (GHS-R) to stimulate GH release from the pituitary. Also has some direct effects on the hypothalamus. Causes less appetite increase than GHRP-6.	Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.	Binds to GHRH receptors in the pituitary gland to stimulate natural GH production and release. Maintains the body's natural feedback mechanisms for GH regulation.
Typical Dosage	Typical dosing: 100-300mcg administered 2-3 times daily. Often stacked with GHRH peptides for enhanced GH release.	Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.	Typical dosing: 200-500mcg administered once daily, usually before bed. Some protocols use twice daily dosing.
Administration	Subcutaneous injection on an empty stomach. Can be used at bedtime to enhance natural GH pulse during sleep.	Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.	Subcutaneous injection, preferably at bedtime to work with natural GH release patterns. Can be combined with GHRPs for synergistic effects.
Side Effects	Moderate hunger increase, water retention, potential prolactin and cortisol elevation (less than GHRP-6), tingling sensations.	Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.	Generally well-tolerated. May cause injection site reactions, headache, flushing, or dizziness. Less side effects than direct GH administration.
Best For	Muscle Growth Fat Loss Sleep Quality	Muscle Growth Recovery & Healing	Muscle Growth Fat Loss Recovery & Healing Sleep Quality