Substance P
Substance P is an 11-amino acid neuropeptide involved in pain transmission, inflammation, and various neurological processes. While not used therapeutically itself, understanding it is crucial for pain research.
Mechanism of Action
Binds primarily to NK1 receptors to transmit pain signals from peripheral nerves to the CNS. Also promotes inflammation, causes vasodilation, and stimulates immune cells.
Dosage Overview
Dose Range
35 mcg – 350 mcg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1 weeks
Reconstitution
Typical Dosage (Research)
Not used as a therapeutic agent. NK1 receptor antagonists (blocking Substance P) are used clinically for chemotherapy-induced nausea.
Research compound only. Therapeutic applications focus on blocking rather than administering Substance P.
Considerations for Men & Women
Women: Neuropeptide involved in pain signaling and inflammation. Women generally have higher substance P levels and may be more sensitive to its effects. Research doses are weight-based, so absolute doses differ. Relevant to fibromyalgia research, which disproportionately affects women.
Men: Lower baseline substance P levels. Same weight-based research dosing. Acute use only — not a chronic therapy.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Concentration: 2.5 mg/ml
Volume to inject: 0.01 ml
Syringe units (U-100): 1.4 units
Pre-filled with Substance P defaults. Adjust values as needed.
Side Effects & Risks
Administration would cause pain, inflammation, and neurogenic responses. Not given therapeutically.
Exogenous administration would be harmful. Research focuses on antagonists not agonists.
Who Uses Substance P
Pain researchers, neuroscientists studying nociception, those researching neurogenic inflammation.
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