Substance P
Substance P is an 11-amino acid neuropeptide involved in pain transmission, inflammation, and various neurological processes. While not used therapeutically itself, understanding it is crucial for pain research.
Mechanism of Action
Binds primarily to NK1 receptors to transmit pain signals from peripheral nerves to the CNS. Also promotes inflammation, causes vasodilation, and stimulates immune cells.
Typical Dosage (Research)
Not used as a therapeutic agent. NK1 receptor antagonists (blocking Substance P) are used clinically for chemotherapy-induced nausea.
Research compound only. Therapeutic applications focus on blocking rather than administering Substance P.
Side Effects & Risks
Administration would cause pain, inflammation, and neurogenic responses. Not given therapeutically.
Exogenous administration would be harmful. Research focuses on antagonists not agonists.
Who Uses Substance P
Pain researchers, neuroscientists studying nociception, those researching neurogenic inflammation.