Cortexin vs Substance P

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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Substance P

Substance P is an 11-amino acid neuropeptide involved in pain transmission, inflammation, and various neurological processes. While not used therapeutically itself, understanding it is crucial for pain research.

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Side-by-Side Comparison

Aspect	Cortexin	Substance P
Dose Range	10 mg–20 mg	35 mcg–350 mcg
Frequency	1x daily	1x daily
Cycle Length	1–2 weeks	1 weeks
Route	intramuscular	subcutaneous
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	Binds primarily to NK1 receptors to transmit pain signals from peripheral nerves to the CNS. Also promotes inflammation, causes vasodilation, and stimulates immune cells.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Not used as a therapeutic agent. NK1 receptor antagonists (blocking Substance P) are used clinically for chemotherapy-induced nausea.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Research compound only. Therapeutic applications focus on blocking rather than administering Substance P.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	Administration would cause pain, inflammation, and neurogenic responses. Not given therapeutically.
Best For	Recovery & Healing Cognitive Performance	Cognitive Performance