SNAP-8
SNAP-8 (Acetyl Octapeptide-3) is a cosmetic peptide that reduces the appearance of wrinkles by modulating muscle contraction. It is often called 'topical Botox' though it works through a different mechanism.
Mechanism of Action
Mimics the N-terminal end of SNAP-25, competing with native SNAP-25 for position in the SNARE complex. This reduces neurotransmitter release at the neuromuscular junction, decreasing muscle contraction.
Dosage Overview
Dose Range
500 mcg – 1 mg
Route
topical
Frequency
1x daily
Cycle Length
4–8 weeks
Reconstitution
Typical Dosage (Research)
Topical: 3-10% concentration in serums or creams, applied 1-2 times daily to target areas (forehead, crow's feet, etc.).
Topical application only. Should be applied to clean skin. Often formulated with penetration enhancers for better absorption.
Considerations for Men & Women
Women: Acetyl octapeptide-3 used topically as a "Botox alternative" for expression lines. More commonly marketed to and studied in women for anti-aging skincare. No systemic sex-specific effects with topical use.
Men: Same anti-wrinkle mechanism. Less commonly marketed to men but equally effective. Topical application only — no sex-specific considerations.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 2,500 mcg/ml
Volume to inject: 0.20 ml
Syringe units (U-100): 20.0 units
Pre-filled with SNAP-8 defaults. Adjust values as needed.
Side Effects & Risks
Generally well-tolerated topically. Rare reports of mild skin irritation. No systemic effects at cosmetic doses.
Effects are temporary and subtle compared to injectable neurotoxins. Quality and concentration vary widely between products.
Where to Buy SNAP-8
All Vendor Details →US-based vendor with third-party HPLC testing and published COAs. One of the few reputable sources we've verified for research-grade peptides.
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Finnrick grades are based on independent HPLC lab testing. Learn more · Finnrick is a commercial service — ratings are third-party, not independent.
Who Uses SNAP-8
Those seeking non-invasive wrinkle reduction, individuals looking to extend time between Botox treatments.
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