Noopept

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.

Mechanism of Action

Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms.

Typical Dosage (Research)

Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau.

Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food.

Side Effects & Risks

Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use.

May lower emotional sensitivity in some users. Should be cycled to prevent tolerance. Interactions with other nootropics possible.

Who Uses Noopept

Students, professionals seeking cognitive enhancement, nootropic enthusiasts, those looking for an oral peptide-derived nootropic.