Noopept
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.
Mechanism of Action
Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms.
Dosage Overview
Dose Range
10 mg – 30 mg
Route
oral
Frequency
2x daily
Cycle Length
4–6 weeks
Reconstitution
Typical Dosage (Research)
Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau.
Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food.
Considerations for Men & Women
Women: Widely studied nootropic. No significant sex-specific differences in cognitive enhancement. May have mild anxiolytic effects. No known interactions with hormonal contraceptives.
Men: Same cognitive benefits. Oral administration with good bioavailability. Can be combined with choline sources for enhanced effect in both sexes.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 5,000 mcg/ml
Volume to inject: 2.00 ml
Syringe units (U-100): 200.0 units
Pre-filled with Noopept defaults. Adjust values as needed.
Side Effects & Risks
Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use.
May lower emotional sensitivity in some users. Should be cycled to prevent tolerance. Interactions with other nootropics possible.
Who Uses Noopept
Students, professionals seeking cognitive enhancement, nootropic enthusiasts, those looking for an oral peptide-derived nootropic.
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