Noopept vs PE-22-28

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Noopept

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.

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PE-22-28

PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.

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Side-by-Side Comparison

Aspect	Noopept	PE-22-28
Dose Range	10 mg–30 mg	500 mcg–2 mg
Frequency	2x daily	1x daily
Cycle Length	4–6 weeks	1–2 weeks
Route	oral	subcutaneous
Mechanism	Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms.	Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways.
Typical Dosage	Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau.	Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established.
Administration	Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food.	Intranasal administration preferred for CNS delivery. Research compound with limited human use data.
Side Effects	Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use.	Very limited human data. Primarily studied in animal models for safety and efficacy.
Best For	Cognitive Performance	Cognitive Performance Anti-Aging & Longevity