VIP (Vasoactive Intestinal Peptide) vs GHRP-2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
VIP (Vasoactive Intestinal Peptide)
VIP is a 28-amino acid neuropeptide with wide-ranging effects throughout the body. It acts as a neurotransmitter, neuromodulator, and immune regulator with particular importance in gut and lung function.
Full details →GHRP-2
Growth Hormone Releasing Peptide 2 (GHRP-2) is considered one of the most potent GHRPs available. It provides strong GH release with moderate hunger increase compared to GHRP-6.
Full details →Side-by-Side Comparison
| Aspect | VIP (Vasoactive Intestinal Peptide) | GHRP-2 |
|---|---|---|
| Mechanism | Binds to VPAC1 and VPAC2 receptors to modulate immune responses, regulate circadian rhythms, promote vasodilation, and support barrier function in gut and lungs. Has potent anti-inflammatory effects. | Binds to the ghrelin receptor (GHS-R) to stimulate GH release from the pituitary. Also has some direct effects on the hypothalamus. Causes less appetite increase than GHRP-6. |
| Typical Dosage | Intranasal: 50-200mcg 1-3 times daily for chronic inflammatory conditions. Some protocols use subcutaneous administration. Dosing varies by condition. | Typical dosing: 100-300mcg administered 2-3 times daily. Often stacked with GHRH peptides for enhanced GH release. |
| Administration | Intranasal is most common for inflammatory conditions. Subcutaneous injection also used. Must be stored cold and protected from light. | Subcutaneous injection on an empty stomach. Can be used at bedtime to enhance natural GH pulse during sleep. |
| Side Effects | May cause nasal irritation, flushing, headache, or temporary diarrhea. Generally well-tolerated at standard doses. | Moderate hunger increase, water retention, potential prolactin and cortisol elevation (less than GHRP-6), tingling sensations. |
| Best For |
What They Have in Common
Both VIP (Vasoactive Intestinal Peptide) and GHRP-2 are commonly used for:
Key Differences
Unique to VIP (Vasoactive Intestinal Peptide):
Unique to GHRP-2:
Detailed Analysis
Both GHRP-2 and VIP (Vasoactive Intestinal Peptide) are commonly used for Sleep Quality.
Which Should You Choose?
Both peptides have similar evidence levels for their shared goals. Your choice may depend on specific use case, availability, or personal response.