NA-Selank Amidate vs Semax

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

NA-Selank Amidate

NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.

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Semax

Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent.

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Side-by-Side Comparison

Aspect	NA-Selank Amidate	Semax
Dose Range	300 mcg–900 mcg	300 mcg–600 mcg
Frequency	2x daily	2x daily
Cycle Length	2–4 weeks	2–4 weeks
Route	intranasal	intranasal
Mechanism	Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability.	Enhances BDNF expression, modulates dopamine and serotonin systems, and provides neuroprotective effects. Increases attention, memory formation, and learning.
Typical Dosage	Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability.	Intranasal: 200-600mcg 2-3 times daily. Higher doses (up to 1mg) used in clinical settings for stroke recovery.
Administration	Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank.	Primarily administered intranasally. N-Acetyl Semax Amidate (NASA) is a modified version with enhanced stability and potency.
Side Effects	Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank.	Generally well-tolerated. May cause mild irritability or hair shedding in some users.
Best For	Cognitive Performance Immune Support	Cognitive Performance