NA-Selank Amidate vs PE-22-28
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Side-by-Side Comparison
| Aspect | NA-Selank Amidate | PE-22-28 |
|---|---|---|
| Dose Range | 300 mcg–900 mcg | 500 mcg–2 mg |
| Frequency | 2x daily | 1x daily |
| Cycle Length | 2–4 weeks | 1–2 weeks |
| Route | intranasal | subcutaneous |
| Mechanism | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. |
| Typical Dosage | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. |
| Administration | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. |
| Side Effects | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. | Very limited human data. Primarily studied in animal models for safety and efficacy. |
| Best For |
What They Have in Common
NA-Selank Amidate, PE-22-28 are both commonly used for:
Key Differences
Unique to NA-Selank Amidate:
Unique to PE-22-28:
Which Has Stronger Evidence?
- Cognitive Performance: NA-Selank Amidate has stronger research support.
| Goal | NA-Selank Amidate | PE-22-28 |
|---|---|---|
| Cognitive Performance | medium | low |
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