NA-Selank Amidate vs Noopept
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Noopept
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.
Full details →Side-by-Side Comparison
| Aspect | NA-Selank Amidate | Noopept |
|---|---|---|
| Dose Range | 300 mcg–900 mcg | 10 mg–30 mg |
| Frequency | 2x daily | 2x daily |
| Cycle Length | 2–4 weeks | 4–6 weeks |
| Route | intranasal | oral |
| Mechanism | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. | Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms. |
| Typical Dosage | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. | Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau. |
| Administration | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. | Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food. |
| Side Effects | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. | Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use. |
| Best For |
What They Have in Common
NA-Selank Amidate, Noopept are both commonly used for:
Key Differences
Unique to NA-Selank Amidate:
Which Has Stronger Evidence?
| Goal | NA-Selank Amidate | Noopept |
|---|---|---|
| Cognitive Performance | medium | medium |
Key Studies
Noopept
- Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2023
- Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats.
International journal of molecular sciences, 2022
- Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process.
Heliyon, 2021
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