Lactoferricin vs NA-Selank Amidate
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Lactoferricin
Lactoferricin is an antimicrobial peptide derived from lactoferrin, a protein found in milk and other secretions. It has potent antibacterial, antiviral, and antifungal properties.
Full details →NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Side-by-Side Comparison
| Aspect | Lactoferricin | NA-Selank Amidate |
|---|---|---|
| Dose Range | 100 mcg–500 mcg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 2–4 weeks | 2–4 weeks |
| Route | subcutaneous | intranasal |
| Mechanism | Binds to and disrupts microbial membranes through electrostatic interactions. Also binds to lipopolysaccharide (LPS) to neutralize endotoxins and has immunomodulatory effects. | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. |
| Typical Dosage | Research applications vary widely. Oral lactoferrin supplements (containing lactoferricin precursor) typically dosed at 100-400mg daily. | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. |
| Administration | Available through lactoferrin supplementation orally. Purified lactoferricin primarily used in research settings. | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. |
| Side Effects | Lactoferrin supplementation is generally well-tolerated. May cause GI upset in some individuals. Derived from milk so caution with dairy allergies. | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. |
| Best For |
What They Have in Common
Lactoferricin, NA-Selank Amidate are both commonly used for:
Key Differences
Unique to Lactoferricin:
Unique to NA-Selank Amidate:
Which Has Stronger Evidence?
- Immune Support: Lactoferricin has stronger research support.
| Goal | Lactoferricin | NA-Selank Amidate |
|---|---|---|
| Immune Support | high | low |
Key Studies
Lactoferricin
- Lactoferricin enables adenovirus infection of human skeletal muscle cells.
Npj viruses, 2025
- Lactoferricin, an antimicrobial motif derived from lactoferrin with food preservation potential.
Critical reviews in food science and nutrition, 2024
- Expression and antimicrobial activity of the recombinant bovine lactoferricin in Pichia pastoris.
Synthetic and systems biotechnology, 2024
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