Humanin vs Semax

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Humanin

Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.

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Semax

Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent.

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Side-by-Side Comparison

Aspect	Humanin	Semax
Dose Range	100 mcg–500 mcg	300 mcg–600 mcg
Frequency	1x daily	2x daily
Cycle Length	4–8 weeks	2–4 weeks
Route	subcutaneous	intranasal
Mechanism	Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.	Enhances BDNF expression, modulates dopamine and serotonin systems, and provides neuroprotective effects. Increases attention, memory formation, and learning.
Typical Dosage	Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.	Intranasal: 200-600mcg 2-3 times daily. Higher doses (up to 1mg) used in clinical settings for stroke recovery.
Administration	Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.	Primarily administered intranasally. N-Acetyl Semax Amidate (NASA) is a modified version with enhanced stability and potency.
Side Effects	Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.	Generally well-tolerated. May cause mild irritability or hair shedding in some users.
Best For	Cognitive Performance Anti-Aging & Longevity	Cognitive Performance