Human Growth Hormone (HGH) vs MGF (Mechano Growth Factor) vs Sermorelin
A three-way comparison to help you find the right peptide for your research goals.
Human Growth Hormone (HGH)
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Full details →MGF (Mechano Growth Factor)
MGF (Mechano Growth Factor) is a splice variant of IGF-1 that is produced locally in muscle tissue in response to mechanical stress. The non-PEGylated form has a very short half-life.
Full details →Sermorelin
Sermorelin is a synthetic analog of GHRH consisting of the first 29 amino acids of the natural hormone. It was previously FDA-approved for GH deficiency diagnosis and treatment in children.
Full details →Side-by-Side Comparison
| Aspect | Human Growth Hormone (HGH) | MGF (Mechano Growth Factor) | Sermorelin |
|---|---|---|---|
| Mechanism | Binds to GH receptors throughout the body, stimulating IGF-1 production in the liver. Promotes protein synthesis, fat metabolism, and cellular regeneration across multiple tissues. | Activates muscle satellite cells (stem cells) and promotes their proliferation without differentiation, priming them for fusion with existing muscle fibers during repair and growth. | Binds to GHRH receptors in the pituitary gland to stimulate natural GH production and release. Maintains the body's natural feedback mechanisms for GH regulation. |
| Typical Dosage | Medical: 0.1-0.3mg/kg/week divided into daily doses. Anti-aging: 1-2 IU daily. Performance: 2-6 IU daily, sometimes higher. | Due to extremely short half-life (minutes), typical protocols use 100-200mcg injected directly into target muscles immediately post-workout. | Typical dosing: 200-500mcg administered once daily, usually before bed. Some protocols use twice daily dosing. |
| Administration | Subcutaneous injection, preferably at night to mimic natural pulsatile release. Rotate injection sites. Store refrigerated. | Intramuscular injection into trained muscles within minutes of workout completion. Must be used immediately after reconstitution due to instability. | Subcutaneous injection, preferably at bedtime to work with natural GH release patterns. Can be combined with GHRPs for synergistic effects. |
| Side Effects | Joint pain, water retention, carpal tunnel syndrome, potential insulin resistance, and acromegaly features with long-term high doses. | Injection site soreness, potential hypoglycemia, localized swelling. Short half-life limits systemic effects. | Generally well-tolerated. May cause injection site reactions, headache, flushing, or dizziness. Less side effects than direct GH administration. |
| Best For |
What They Have in Common
Human Growth Hormone (HGH), MGF (Mechano Growth Factor), Sermorelin are all commonly used for:
Key Differences
Unique to Human Growth Hormone (HGH):
Unique to Sermorelin:
Detailed Analysis
Commonalities
Both Human Growth Hormone (HGH) and MGF (Mechano Growth Factor) are commonly used for Muscle Growth, Recovery & Healing.
Which Should You Choose?
Human Growth Hormone (HGH) has stronger evidence for Muscle Growth, Recovery & Healing.
Commonalities
Both Human Growth Hormone (HGH) and Sermorelin are commonly used for Muscle Growth, Fat Loss, Recovery & Healing, Sleep Quality.
Which Should You Choose?
Human Growth Hormone (HGH) has stronger evidence for Muscle Growth, Fat Loss, Recovery & Healing.
Commonalities
Both MGF (Mechano Growth Factor) and Sermorelin are commonly used for Muscle Growth, Recovery & Healing.
Which Should You Choose?
Both peptides have similar evidence levels for their shared goals. Your choice may depend on specific use case, availability, or personal response.