GHRP-6 vs Ipamorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.

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Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland without significantly affecting cortisol or prolactin.

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Side-by-Side Comparison

Aspect	GHRP-6	Ipamorelin
Dose Range	100 mcg–300 mcg	100 mcg–300 mcg
Frequency	3x daily	2x daily
Cycle Length	8–12 weeks	8–12 weeks
Route	subcutaneous	subcutaneous
Mechanism	Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.	Acts as a ghrelin mimetic, binding to the ghrelin receptor (GHS-R) in the pituitary to stimulate GH release. Highly selective with minimal effect on other hormones.
Typical Dosage	Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.	Typical dosing ranges from 200-300mcg administered 2-3 times daily, often combined with CJC-1295.
Administration	Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.	Subcutaneous injection. Best results when administered fasted or before sleep. Often stacked with GHRH peptides.
Side Effects	Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.	Generally well-tolerated. May cause mild headaches, lightheadedness, or increased hunger initially.
Best For	Muscle Growth Recovery & Healing	Muscle Growth Fat Loss Recovery & Healing Sleep Quality