FGL vs NA-Selank Amidate
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
FGL
FGL (FG Loop) is a synthetic peptide that mimics the neural cell adhesion molecule (NCAM) FG loop region. It promotes neuroplasticity and has shown cognitive-enhancing effects in research.
Full details →NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Side-by-Side Comparison
| Aspect | FGL | NA-Selank Amidate |
|---|---|---|
| Dose Range | 500 mcg–1 mg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 4–8 weeks | 2–4 weeks |
| Route | intranasal | intranasal |
| Mechanism | Binds to FGFR1 (fibroblast growth factor receptor 1) to activate downstream signaling cascades that promote neurite outgrowth, synaptic plasticity, and neuronal survival. | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. |
| Typical Dosage | Research protocols have used subcutaneous doses ranging from 1-10mg. Intranasal administration also studied. Optimal dosing not established. | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. |
| Administration | Subcutaneous injection or intranasal administration. Research compound with limited human dosing data. | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. |
| Side Effects | Limited human data available. Animal studies show good tolerability. | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. |
| Best For |
What They Have in Common
FGL, NA-Selank Amidate are both commonly used for:
Key Differences
Unique to NA-Selank Amidate:
Which Has Stronger Evidence?
| Goal | FGL | NA-Selank Amidate |
|---|---|---|
| Cognitive Performance | medium | medium |
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