DSIP vs VIP (Vasoactive Intestinal Peptide)

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

DSIP

Delta Sleep-Inducing Peptide is a neuropeptide that promotes delta wave sleep, the deepest and most restorative phase of the sleep cycle.

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VIP (Vasoactive Intestinal Peptide)

VIP is a 28-amino acid neuropeptide with wide-ranging effects throughout the body. It acts as a neurotransmitter, neuromodulator, and immune regulator with particular importance in gut and lung function.

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Side-by-Side Comparison

Aspect	DSIP	VIP (Vasoactive Intestinal Peptide)
Dose Range	100 mcg–300 mcg	100 mcg–200 mcg
Frequency	1x daily	1x daily
Cycle Length	1–6 weeks	2–8 weeks
Route	subcutaneous	intranasal
Mechanism	Modulates sleep-wake cycles by affecting sleep spindles and delta rhythms. May also influence stress hormones and have analgesic properties.	Binds to VPAC1 and VPAC2 receptors to modulate immune responses, regulate circadian rhythms, promote vasodilation, and support barrier function in gut and lungs. Has potent anti-inflammatory effects.
Typical Dosage	Typical dosing: 100-300mcg administered 30 minutes before sleep. Some protocols use it cyclically.	Intranasal: 50-200mcg 1-3 times daily for chronic inflammatory conditions. Some protocols use subcutaneous administration. Dosing varies by condition.
Administration	Subcutaneous or intramuscular injection before bedtime. Some users report better results with cyclical use.	Intranasal is most common for inflammatory conditions. Subcutaneous injection also used. Must be stored cold and protected from light.
Side Effects	May cause grogginess upon waking, vivid dreams, or temporary headaches.	May cause nasal irritation, flushing, headache, or temporary diarrhea. Generally well-tolerated at standard doses.
Best For	Recovery & Healing Sleep Quality	Sleep Quality Immune Support Gut Health