DSIP vs Human Growth Hormone (HGH) vs MK-677 (Ibutamoren)
A three-way comparison to help you find the right peptide for your research goals.
DSIP
Delta Sleep-Inducing Peptide is a neuropeptide that promotes delta wave sleep, the deepest and most restorative phase of the sleep cycle.
Full details →Human Growth Hormone (HGH)
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Full details →MK-677 (Ibutamoren)
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue. Unlike peptides, it can be taken orally and has a long half-life, providing 24-hour GH elevation.
Full details →Side-by-Side Comparison
| Aspect | DSIP | Human Growth Hormone (HGH) | MK-677 (Ibutamoren) |
|---|---|---|---|
| Mechanism | Modulates sleep-wake cycles by affecting sleep spindles and delta rhythms. May also influence stress hormones and have analgesic properties. | Binds to GH receptors throughout the body, stimulating IGF-1 production in the liver. Promotes protein synthesis, fat metabolism, and cellular regeneration across multiple tissues. | Acts as a potent, selective agonist of the ghrelin receptor (GHS-R1a). Increases GH and IGF-1 levels without affecting cortisol. Mimics ghrelin's GH-releasing effects. |
| Typical Dosage | Typical dosing: 100-300mcg administered 30 minutes before sleep. Some protocols use it cyclically. | Medical: 0.1-0.3mg/kg/week divided into daily doses. Anti-aging: 1-2 IU daily. Performance: 2-6 IU daily, sometimes higher. | Typical dosing: 10-25mg taken orally once daily. Often taken at night due to sleep benefits and appetite increase. |
| Administration | Subcutaneous or intramuscular injection before bedtime. Some users report better results with cyclical use. | Subcutaneous injection, preferably at night to mimic natural pulsatile release. Rotate injection sites. Store refrigerated. | Oral administration (capsule or liquid). Can be taken with or without food. Long half-life allows once-daily dosing. |
| Side Effects | May cause grogginess upon waking, vivid dreams, or temporary headaches. | Joint pain, water retention, carpal tunnel syndrome, potential insulin resistance, and acromegaly features with long-term high doses. | Increased appetite and water retention are most common. May cause lethargy, vivid dreams, and mild numbness. Can affect blood glucose and insulin sensitivity. |
| Best For |
What They Have in Common
DSIP, Human Growth Hormone (HGH), MK-677 (Ibutamoren) are all commonly used for:
Key Differences
Unique to Human Growth Hormone (HGH):
Unique to MK-677 (Ibutamoren):
Detailed Analysis
Commonalities
Both DSIP and Human Growth Hormone (HGH) are commonly used for Recovery & Healing, Sleep Quality.
Which Should You Choose?
DSIP has stronger evidence for Sleep Quality. Human Growth Hormone (HGH) has stronger evidence for Recovery & Healing.
Commonalities
Both DSIP and MK-677 (Ibutamoren) are commonly used for Recovery & Healing, Sleep Quality.
Which Should You Choose?
Both peptides have similar evidence levels for their shared goals. Your choice may depend on specific use case, availability, or personal response.
Commonalities
Both Human Growth Hormone (HGH) and MK-677 (Ibutamoren) are commonly used for Muscle Growth, Fat Loss, Recovery & Healing, Sleep Quality.
Which Should You Choose?
Human Growth Hormone (HGH) has stronger evidence for Fat Loss, Recovery & Healing. MK-677 (Ibutamoren) has stronger evidence for Sleep Quality.