Kisspeptin-10
Kisspeptin-10 is the active fragment of kisspeptin, a hormone that plays a crucial role in initiating puberty and regulating reproductive function. It acts upstream of GnRH in the hypothalamic-pituitary-gonadal axis.
Mechanism of Action
Binds to KISS1R receptors in the hypothalamus, stimulating GnRH neurons to release GnRH. This triggers the downstream cascade of LH, FSH, and sex hormone production.
Dosage Overview
Dose Range
100 mcg – 1 mg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1–4 weeks
Reconstitution
Typical Dosage (Research)
Research protocols vary widely. Studies have used IV boluses of 1-10mcg/kg or subcutaneous administration. Clinical applications still being developed.
IV or subcutaneous injection. Has very short half-life requiring frequent administration or continuous infusion for sustained effects.
Considerations for Men & Women
Women: Plays a central role in reproductive endocrinology. Used in fertility research as an alternative to hCG for triggering oocyte maturation in IVF protocols, with potentially lower risk of ovarian hyperstimulation syndrome (OHSS). Kisspeptin levels fluctuate across the menstrual cycle and are elevated during pregnancy.
Men: Stimulates GnRH release, leading to increased LH and testosterone secretion. Research interest centers on its potential as a diagnostic tool for hypothalamic amenorrhea equivalents and as a testosterone-boosting agent that works through the natural HPG axis rather than exogenous replacement.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 1,000 mcg/ml
Volume to inject: 0.10 ml
Syringe units (U-100): 10.0 units
Pre-filled with Kisspeptin-10 defaults. Adjust values as needed.
Side Effects & Risks
Limited data. May cause flushing, increased heart rate, and changes in libido. Generally well-tolerated in studies.
Research stage peptide. May cause unpredictable hormonal effects. Not suitable for those with hormone-sensitive conditions.
Where to Buy Kisspeptin-10
All Vendor Details →US-based vendor with third-party HPLC testing and published COAs. One of the few reputable sources we've verified for research-grade peptides.
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Who Uses Kisspeptin-10
Researchers studying reproductive function, those with hypothalamic amenorrhea, individuals exploring advanced hormone optimization.
Similar Peptides
View All Alternatives →Melanotan II is a synthetic peptide analog of α-MSH with broader receptor activity than Melanotan I. It produces tanning effects and has notable effects on sexual function and appetite suppression.
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH). It stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), supporting natural hormone production.