Kisspeptin-10

Kisspeptin-10 is the active fragment of kisspeptin, a hormone that plays a crucial role in initiating puberty and regulating reproductive function. It acts upstream of GnRH in the hypothalamic-pituitary-gonadal axis.

Mechanism of Action

Binds to KISS1R receptors in the hypothalamus, stimulating GnRH neurons to release GnRH. This triggers the downstream cascade of LH, FSH, and sex hormone production.

Typical Dosage (Research)

Research protocols vary widely. Studies have used IV boluses of 1-10mcg/kg or subcutaneous administration. Clinical applications still being developed.

IV or subcutaneous injection. Has very short half-life requiring frequent administration or continuous infusion for sustained effects.

Side Effects & Risks

Limited data. May cause flushing, increased heart rate, and changes in libido. Generally well-tolerated in studies.

Research stage peptide. May cause unpredictable hormonal effects. Not suitable for those with hormone-sensitive conditions.

Who Uses Kisspeptin-10

Researchers studying reproductive function, those with hypothalamic amenorrhea, individuals exploring advanced hormone optimization.