Melanotan II
Melanotan II is a synthetic peptide analog of α-MSH with broader receptor activity than Melanotan I. It produces tanning effects and has notable effects on sexual function and appetite suppression.
Mechanism of Action
Non-selective melanocortin receptor agonist affecting MC1R (tanning), MC3R and MC4R (sexual function and appetite). This broader activity explains its multiple effects beyond tanning.
Typical Dosage (Research)
Typical protocols: 0.25-0.5mg daily during loading phase for 1-2 weeks, then 0.5-1mg before UV exposure for maintenance. Start low to assess tolerance.
Subcutaneous injection. Usually combined with UV exposure for tanning effects. Nasal spray formulations exist but have lower bioavailability.
Side Effects & Risks
Nausea (common initially), facial flushing, spontaneous erections, increased libido, appetite suppression, and mole darkening.
May promote melanoma growth in predisposed individuals. Can cause priapism. Mole changes require monitoring. Not FDA approved.
Who Uses Melanotan II
Those seeking tanning without extensive sun exposure, individuals interested in libido enhancement, bodybuilders before competitions.