Melanotan II
Melanotan II is a synthetic peptide analog of α-MSH with broader receptor activity than Melanotan I. It produces tanning effects and has notable effects on sexual function and appetite suppression.
Mechanism of Action
Non-selective melanocortin receptor agonist affecting MC1R (tanning), MC3R and MC4R (sexual function and appetite). This broader activity explains its multiple effects beyond tanning.
Dosage Overview
Dose Range
250 mcg – 1 mg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1–2 weeks
Reconstitution
Typical Dosage (Research)
Typical protocols: 0.25-0.5mg daily during loading phase for 1-2 weeks, then 0.5-1mg before UV exposure for maintenance. Start low to assess tolerance.
Subcutaneous injection. Usually combined with UV exposure for tanning effects. Nasal spray formulations exist but have lower bioavailability.
Considerations for Men & Women
Women: Produces tanning and may increase libido/arousal, though sexual effects are less predictable than in men. Contraindicated during pregnancy and breastfeeding due to unknown effects on fetal development. May affect menstrual cycle regularity in some users. Nausea tends to be more common at initiation.
Men: Frequently reported to cause spontaneous erections and increased libido alongside tanning effects. Sexual side effects are more pronounced and consistent in men. Often used specifically for both tanning and sexual function enhancement.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Concentration: 5 mg/ml
Volume to inject: 0.05 ml
Syringe units (U-100): 5.0 units
Pre-filled with Melanotan II defaults. Adjust values as needed.
Side Effects & Risks
Nausea (common initially), facial flushing, spontaneous erections, increased libido, appetite suppression, and mole darkening.
May promote melanoma growth in predisposed individuals. Can cause priapism. Mole changes require monitoring. Not FDA approved.
Who Uses Melanotan II
Those seeking tanning without extensive sun exposure, individuals interested in libido enhancement, bodybuilders before competitions.
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