Gonadorelin

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH). It stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), supporting natural hormone production.

Mechanism of Action

Binds to GnRH receptors in the pituitary gland, triggering pulsatile release of LH and FSH. This stimulates testicular or ovarian function and natural sex hormone production.

Typical Dosage (Research)

Men: 100-200mcg subcutaneously 2-3 times daily. Women (fertility): Per clinical protocol. HRT support: Often combined with other therapies.

Subcutaneous injection. Pulsatile administration mimics natural GnRH release patterns. Often used during or after testosterone therapy.

Side Effects & Risks

Headache, flushing, injection site reactions. In women may cause ovarian hyperstimulation. Generally well-tolerated.

Continuous (non-pulsatile) administration can actually suppress hormone production. Requires proper protocol design.

Who Uses Gonadorelin

Men on TRT seeking to maintain fertility, individuals addressing hormonal imbalances, fertility treatment.