Gonadorelin
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH). It stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), supporting natural hormone production.
Mechanism of Action
Binds to GnRH receptors in the pituitary gland, triggering pulsatile release of LH and FSH. This stimulates testicular or ovarian function and natural sex hormone production.
Dosage Overview
Dose Range
100 mcg – 200 mcg
Route
subcutaneous
Frequency
2x daily
Cycle Length
8–12 weeks
Reconstitution
Typical Dosage (Research)
Men: 100-200mcg subcutaneously 2-3 times daily. Women (fertility): Per clinical protocol. HRT support: Often combined with other therapies.
Subcutaneous injection. Pulsatile administration mimics natural GnRH release patterns. Often used during or after testosterone therapy.
Considerations for Men & Women
Women: Used in fertility protocols to stimulate FSH and LH release. Pulsatile GnRH administration can restore ovulation in hypothalamic amenorrhea. Also used diagnostically to assess pituitary gonadotropin reserve.
Men: Commonly used as a TRT adjunct to maintain testicular function, intratesticular testosterone, and fertility during exogenous testosterone use. Stimulates endogenous LH and FSH production. Some protocols use it post-cycle to help restore natural hormone production.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Concentration: 2.5 mg/ml
Volume to inject: 0.04 ml
Syringe units (U-100): 4.0 units
Pre-filled with Gonadorelin defaults. Adjust values as needed.
Side Effects & Risks
Headache, flushing, injection site reactions. In women may cause ovarian hyperstimulation. Generally well-tolerated.
Continuous (non-pulsatile) administration can actually suppress hormone production. Requires proper protocol design.
Who Uses Gonadorelin
Men on TRT seeking to maintain fertility, individuals addressing hormonal imbalances, fertility treatment.
Similar Peptides
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Kisspeptin-10 is the active fragment of kisspeptin, a hormone that plays a crucial role in initiating puberty and regulating reproductive function. It acts upstream of GnRH in the hypothalamic-pituitary-gonadal axis.