Dihexa
Dihexa is a nootropic peptide derived from angiotensin IV. It has shown remarkable cognitive-enhancing properties in animal studies, being described as potentially millions of times more potent than BDNF.
Mechanism of Action
Acts as a hepatocyte growth factor (HGF) potentiator by binding to its receptor c-Met. Promotes synaptogenesis, neuronal survival, and cognitive enhancement through this pathway.
Dosage Overview
Dose Range
5 mg – 20 mg
Route
oral
Frequency
1x daily
Cycle Length
4–12 weeks
Reconstitution
Typical Dosage (Research)
Research dosing is highly variable due to extreme potency. Typical range: 10-40mg orally or sublingually. Start with lowest doses due to potency.
Can be taken orally, sublingually, or intranasally. Extremely potent - careful dosing is essential. Best used cyclically.
Considerations for Men & Women
Women: Potent nootropic with angiotensin IV receptor activity. Very limited human data — primarily animal research. Given its extreme potency, conservative dosing is advised for both sexes. Avoid during pregnancy.
Men: Same considerations. Oral administration. Extremely potent — no established sex-specific differences, but limited data overall.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Concentration: 5 mg/ml
Volume to inject: 1.00 ml
Syringe units (U-100): 100.0 units
Pre-filled with Dihexa defaults. Adjust values as needed.
Side Effects & Risks
Limited human data. Reported effects include headache, temporary brain fog during adjustment, and potential mood changes.
Very limited human research data. Theoretical concerns about promoting growth of existing cancers through HGF pathway. Long-term safety unknown.
Who Uses Dihexa
Researchers, advanced nootropic users, those with cognitive decline seeking experimental options.
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