SS-31 (Elamipretide) vs Semax
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide or Bendavia, is a mitochondria-targeted tetrapeptide. It has been studied extensively for mitochondrial diseases, heart failure, and age-related decline in mitochondrial function.
Full details →Semax
Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent.
Full details →Side-by-Side Comparison
| Aspect | SS-31 (Elamipretide) | Semax |
|---|---|---|
| Mechanism | Concentrates in the inner mitochondrial membrane where it binds to cardiolipin, stabilizing electron transport chain function, reducing reactive oxygen species, and improving ATP production efficiency. | Enhances BDNF expression, modulates dopamine and serotonin systems, and provides neuroprotective effects. Increases attention, memory formation, and learning. |
| Typical Dosage | Clinical trials have used IV infusions of 0.25mg/kg for acute conditions. Subcutaneous dosing protocols for research use typically range from 1-5mg daily. | Intranasal: 200-600mcg 2-3 times daily. Higher doses (up to 1mg) used in clinical settings for stroke recovery. |
| Administration | Can be administered IV or subcutaneously. Most clinical research has used IV administration for cardiac conditions. | Primarily administered intranasally. N-Acetyl Semax Amidate (NASA) is a modified version with enhanced stability and potency. |
| Side Effects | Generally well-tolerated. Clinical trials reported injection site reactions and occasional headache. | Generally well-tolerated. May cause mild irritability or hair shedding in some users. |
| Best For |
Key Differences
Unique to SS-31 (Elamipretide):
Unique to Semax:
Detailed Analysis
SS-31 (Elamipretide) and Semax are used for different purposes and have limited overlap in their applications.
Which Should You Choose?
Choose SS-31 (Elamipretide) for Recovery & Healing, Anti-Aging & Longevity. Choose Semax for Cognitive Performance.