Semax vs Epithalamin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Semax
Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent.
Full details →Epithalamin
Epithalamin is a natural peptide extract from the pineal gland. It is the precursor compound from which the synthetic Epitalon was derived. Known for anti-aging and telomerase-activating properties.
Full details →Side-by-Side Comparison
| Aspect | Semax | Epithalamin |
|---|---|---|
| Mechanism | Enhances BDNF expression, modulates dopamine and serotonin systems, and provides neuroprotective effects. Increases attention, memory formation, and learning. | Similar to Epitalon, it stimulates telomerase production and may help maintain telomere length. Also regulates melatonin synthesis and circadian rhythms. |
| Typical Dosage | Intranasal: 200-600mcg 2-3 times daily. Higher doses (up to 1mg) used in clinical settings for stroke recovery. | Research dosing: 10-20mg daily for 10-20 day cycles. Often administered 1-3 times per year in long-term protocols. |
| Administration | Primarily administered intranasally. N-Acetyl Semax Amidate (NASA) is a modified version with enhanced stability and potency. | Intramuscular or subcutaneous injection. Natural extract may have more variable composition than synthetic Epitalon. |
| Side Effects | Generally well-tolerated. May cause mild irritability or hair shedding in some users. | Generally well-tolerated. May affect sleep patterns. Less characterized than synthetic Epitalon. |
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