Selank vs Dihexa
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Selank
Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.
Full details →Dihexa
Dihexa is a nootropic peptide derived from angiotensin IV. It has shown remarkable cognitive-enhancing properties in animal studies, being described as potentially millions of times more potent than BDNF.
Full details →Side-by-Side Comparison
| Aspect | Selank | Dihexa |
|---|---|---|
| Mechanism | Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties. | Acts as a hepatocyte growth factor (HGF) potentiator by binding to its receptor c-Met. Promotes synaptogenesis, neuronal survival, and cognitive enhancement through this pathway. |
| Typical Dosage | Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily. | Research dosing is highly variable due to extreme potency. Typical range: 10-40mg orally or sublingually. Start with lowest doses due to potency. |
| Administration | Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously. | Can be taken orally, sublingually, or intranasally. Extremely potent - careful dosing is essential. Best used cyclically. |
| Side Effects | Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use. | Limited human data. Reported effects include headache, temporary brain fog during adjustment, and potential mood changes. |
| Best For |
What They Have in Common
Both Selank and Dihexa are commonly used for: