PE-22-28 vs Thymulin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Thymulin
Thymulin (Facteur Thymique Sérique) is a zinc-dependent nonapeptide hormone produced by thymic epithelial cells. It plays important roles in T-cell differentiation and immune system maturation.
Full details →Side-by-Side Comparison
| Aspect | PE-22-28 | Thymulin |
|---|---|---|
| Dose Range | 500 mcg–2 mg | 100 mcg–400 mcg |
| Frequency | 1x daily | 1x daily |
| Cycle Length | 1–2 weeks | 4–8 weeks |
| Route | subcutaneous | subcutaneous |
| Mechanism | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. | Requires zinc for biological activity. Promotes T-cell differentiation, modulates cytokine production, and influences neuroendocrine function. Levels decline significantly with age. |
| Typical Dosage | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. | Research protocols vary. Often studied alongside zinc supplementation. Typical research doses in the microgram range. |
| Administration | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. | Subcutaneous or intramuscular injection in research settings. Requires adequate zinc status for activity. |
| Side Effects | Very limited human data. Primarily studied in animal models for safety and efficacy. | Limited data on exogenous administration. Theoretical effects on immune function require monitoring. |
| Best For |
What They Have in Common
PE-22-28, Thymulin are both commonly used for:
Key Differences
Unique to PE-22-28:
Unique to Thymulin:
Which Has Stronger Evidence?
- Anti-Aging & Longevity: Thymulin has stronger research support.
| Goal | PE-22-28 | Thymulin |
|---|---|---|
| Anti-Aging & Longevity | low | medium |
Key Studies
Thymulin
- Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy.
Nature communications, 2026
- Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice.
International journal of immunopathology and pharmacology, 2021
- Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma.
Science advances, 2020
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