Noopept vs SHLP2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Noopept
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.
Full details →SHLP2
SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.
Full details →Side-by-Side Comparison
| Aspect | Noopept | SHLP2 |
|---|---|---|
| Mechanism | Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms. | Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways. |
| Typical Dosage | Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau. | Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established. |
| Administration | Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food. | Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties. |
| Side Effects | Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use. | Limited data. Animal studies suggest good tolerability. May affect glucose metabolism. |
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