NA-Selank Amidate vs Thymalin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Thymalin
Thymalin is a polypeptide preparation derived from calf thymus. Developed in Russia, it has been used for decades to support immune function and has shown potential anti-aging effects in long-term studies.
Full details →Side-by-Side Comparison
| Aspect | NA-Selank Amidate | Thymalin |
|---|---|---|
| Dose Range | 300 mcg–900 mcg | 5 mg–10 mg |
| Frequency | 2x daily | 1x daily |
| Cycle Length | 2–4 weeks | 1–2 weeks |
| Route | intranasal | intramuscular |
| Mechanism | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. | Regulates the ratio of T-cell subpopulations, stimulates cellular immunity, and enhances phagocytosis. Also affects neuroendocrine regulation and may influence melatonin production. |
| Typical Dosage | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. | Clinical protocols: 5-20mg daily intramuscularly for 3-10 days. Often cycled 1-2 times per year for maintenance. |
| Administration | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. | Intramuscular injection. Usually administered in short courses rather than continuously. Often combined with Epithalamin for anti-aging protocols. |
| Side Effects | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. | Generally well-tolerated. May cause injection site reactions or temporary flu-like symptoms as immune function is modulated. |
| Best For |
What They Have in Common
NA-Selank Amidate, Thymalin are both commonly used for:
Key Differences
Unique to NA-Selank Amidate:
Unique to Thymalin:
Which Has Stronger Evidence?
- Immune Support: Thymalin has stronger research support.
| Goal | NA-Selank Amidate | Thymalin |
|---|---|---|
| Immune Support | low | high |
Key Studies
Thymalin
- Reparative osteogenesis in mandible in cases of filling a bone defect with hydroxyapatite-containing osteotropic material and injecting the surrounding soft tissues with thymalin: experimental and morphological study.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 2024
- Expression features of T-lymphocytes, B-lymphocytes and macrophages in the post-traumatic regenerate of the mandible rats under conditions of filling a bone defect with hydroxyapatite-containing osteotropic material and thymalin injecting the surrounding soft tissues.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2024
- The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.
International journal of molecular sciences, 2023
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