NA-Selank Amidate vs Cortexin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
NA-Selank Amidate
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Full details →Cortexin
Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.
Full details →Side-by-Side Comparison
| Aspect | NA-Selank Amidate | Cortexin |
|---|---|---|
| Mechanism | Same core mechanism as Selank - modulates BDNF, serotonin, and norepinephrine systems. The N-acetyl group improves membrane permeability while the amidate modification increases enzymatic stability. | Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized. |
| Typical Dosage | Intranasal: 100-400mcg 1-3 times daily. Lower doses needed compared to standard Selank due to enhanced bioavailability. | Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval. |
| Administration | Primarily intranasal administration. Can be used sublingually. More stable in solution than standard Selank. | Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously. |
| Side Effects | Generally well-tolerated. Possible mild fatigue or nasal irritation. Less frequent dosing needed than standard Selank. | Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals. |
| Best For |
What They Have in Common
Both NA-Selank Amidate and Cortexin are commonly used for:
Key Differences
Unique to NA-Selank Amidate:
Unique to Cortexin:
Detailed Analysis
Both Cortexin and NA-Selank Amidate are commonly used for Cognitive Performance.
Which Should You Choose?
Both peptides have similar evidence levels for their shared goals. Your choice may depend on specific use case, availability, or personal response.