MK-677 (Ibutamoren) vs SHLP2

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue. Unlike peptides, it can be taken orally and has a long half-life, providing 24-hour GH elevation.

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SHLP2

SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.

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Side-by-Side Comparison

Aspect	MK-677 (Ibutamoren)	SHLP2
Dose Range	10 mg–25 mg	1 mg–5 mg
Frequency	1x daily	1x daily
Cycle Length	8–24 weeks	4–8 weeks
Route	oral	subcutaneous
Mechanism	Acts as a potent, selective agonist of the ghrelin receptor (GHS-R1a). Increases GH and IGF-1 levels without affecting cortisol. Mimics ghrelin's GH-releasing effects.	Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways.
Typical Dosage	Typical dosing: 10-25mg taken orally once daily. Often taken at night due to sleep benefits and appetite increase.	Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established.
Administration	Oral administration (capsule or liquid). Can be taken with or without food. Long half-life allows once-daily dosing.	Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties.
Side Effects	Increased appetite and water retention are most common. May cause lethargy, vivid dreams, and mild numbness. Can affect blood glucose and insulin sensitivity.	Limited data. Animal studies suggest good tolerability. May affect glucose metabolism.
Best For	Muscle Growth Fat Loss Recovery & Healing Sleep Quality	Fat Loss Anti-Aging & Longevity