MGF (Mechano Growth Factor) vs Substance P
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
MGF (Mechano Growth Factor)
MGF (Mechano Growth Factor) is a splice variant of IGF-1 that is produced locally in muscle tissue in response to mechanical stress. The non-PEGylated form has a very short half-life.
Full details →Substance P
Substance P is an 11-amino acid neuropeptide involved in pain transmission, inflammation, and various neurological processes. While not used therapeutically itself, understanding it is crucial for pain research.
Full details →Side-by-Side Comparison
| Aspect | MGF (Mechano Growth Factor) | Substance P |
|---|---|---|
| Mechanism | Activates muscle satellite cells (stem cells) and promotes their proliferation without differentiation, priming them for fusion with existing muscle fibers during repair and growth. | Binds primarily to NK1 receptors to transmit pain signals from peripheral nerves to the CNS. Also promotes inflammation, causes vasodilation, and stimulates immune cells. |
| Typical Dosage | Due to extremely short half-life (minutes), typical protocols use 100-200mcg injected directly into target muscles immediately post-workout. | Not used as a therapeutic agent. NK1 receptor antagonists (blocking Substance P) are used clinically for chemotherapy-induced nausea. |
| Administration | Intramuscular injection into trained muscles within minutes of workout completion. Must be used immediately after reconstitution due to instability. | Research compound only. Therapeutic applications focus on blocking rather than administering Substance P. |
| Side Effects | Injection site soreness, potential hypoglycemia, localized swelling. Short half-life limits systemic effects. | Administration would cause pain, inflammation, and neurogenic responses. Not given therapeutically. |
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