Humanin vs Thymulin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Humanin

Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.

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Thymulin

Thymulin (Facteur Thymique Sérique) is a zinc-dependent nonapeptide hormone produced by thymic epithelial cells. It plays important roles in T-cell differentiation and immune system maturation.

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Side-by-Side Comparison

Aspect	Humanin	Thymulin
Dose Range	100 mcg–500 mcg	100 mcg–400 mcg
Frequency	1x daily	1x daily
Cycle Length	4–8 weeks	4–8 weeks
Route	subcutaneous	subcutaneous
Mechanism	Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.	Requires zinc for biological activity. Promotes T-cell differentiation, modulates cytokine production, and influences neuroendocrine function. Levels decline significantly with age.
Typical Dosage	Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.	Research protocols vary. Often studied alongside zinc supplementation. Typical research doses in the microgram range.
Administration	Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.	Subcutaneous or intramuscular injection in research settings. Requires adequate zinc status for activity.
Side Effects	Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.	Limited data on exogenous administration. Theoretical effects on immune function require monitoring.
Best For	Cognitive Performance Anti-Aging & Longevity	Immune Support Anti-Aging & Longevity