Humanin vs Selank

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Humanin

Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.

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Selank

Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.

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Side-by-Side Comparison

Aspect	Humanin	Selank
Dose Range	100 mcg–500 mcg	300 mcg–900 mcg
Frequency	1x daily	2x daily
Cycle Length	4–8 weeks	2–4 weeks
Route	subcutaneous	intranasal
Mechanism	Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.	Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties.
Typical Dosage	Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.	Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily.
Administration	Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.	Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously.
Side Effects	Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.	Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use.
Best For	Cognitive Performance Anti-Aging & Longevity	Cognitive Performance