Humanin vs Pinealon

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Humanin

Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.

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Pinealon

Pinealon is a short synthetic peptide developed from research on the pineal gland. It has shown neuroprotective and cognitive-enhancing properties in animal studies.

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Side-by-Side Comparison

Aspect	Humanin	Pinealon
Dose Range	100 mcg–500 mcg	5 mg–10 mg
Frequency	1x daily	1x daily
Cycle Length	4–8 weeks	1–2 weeks
Route	subcutaneous	subcutaneous
Mechanism	Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress.	Penetrates cell membranes and interacts with DNA to regulate gene expression related to neuronal survival and function. May support pineal gland function and melatonin production.
Typical Dosage	Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog.	Typical dosing: 10-20mg daily, taken in divided doses. Often used in cycles of 10-20 days.
Administration	Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities.	Can be taken orally (capsules) or sublingually. Best absorbed on an empty stomach. Often combined with other neuroprotective peptides.
Side Effects	Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism.	Generally well-tolerated. Limited reported side effects. May affect sleep patterns initially.
Best For	Cognitive Performance Anti-Aging & Longevity	Sleep Quality Cognitive Performance