Human Growth Hormone (HGH) vs MK-677 (Ibutamoren) vs TB-500
A three-way comparison to help you find the right peptide for your research goals.
Human Growth Hormone (HGH)
Human Growth Hormone (somatropin) is a 191-amino acid protein identical to naturally produced GH. FDA-approved for growth hormone deficiency, Turner syndrome, and other conditions. Widely used off-label for anti-aging and performance.
Full details →MK-677 (Ibutamoren)
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue. Unlike peptides, it can be taken orally and has a long half-life, providing 24-hour GH elevation.
Full details →TB-500
Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.
Full details →Side-by-Side Comparison
| Aspect | Human Growth Hormone (HGH) | MK-677 (Ibutamoren) | TB-500 |
|---|---|---|---|
| Mechanism | Binds to GH receptors throughout the body, stimulating IGF-1 production in the liver. Promotes protein synthesis, fat metabolism, and cellular regeneration across multiple tissues. | Acts as a potent, selective agonist of the ghrelin receptor (GHS-R1a). Increases GH and IGF-1 levels without affecting cortisol. Mimics ghrelin's GH-releasing effects. | TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing. |
| Typical Dosage | Medical: 0.1-0.3mg/kg/week divided into daily doses. Anti-aging: 1-2 IU daily. Performance: 2-6 IU daily, sometimes higher. | Typical dosing: 10-25mg taken orally once daily. Often taken at night due to sleep benefits and appetite increase. | Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks. |
| Administration | Subcutaneous injection, preferably at night to mimic natural pulsatile release. Rotate injection sites. Store refrigerated. | Oral administration (capsule or liquid). Can be taken with or without food. Long half-life allows once-daily dosing. | Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites. |
| Side Effects | Joint pain, water retention, carpal tunnel syndrome, potential insulin resistance, and acromegaly features with long-term high doses. | Increased appetite and water retention are most common. May cause lethargy, vivid dreams, and mild numbness. Can affect blood glucose and insulin sensitivity. | May cause temporary fatigue, headache, or localized irritation at injection sites. |
| Best For |
What They Have in Common
Human Growth Hormone (HGH), MK-677 (Ibutamoren), TB-500 are all commonly used for:
Key Differences
Unique to Human Growth Hormone (HGH):
Unique to MK-677 (Ibutamoren):
Detailed Analysis
Commonalities
Both Human Growth Hormone (HGH) and MK-677 (Ibutamoren) are commonly used for Muscle Growth, Fat Loss, Recovery & Healing, Sleep Quality.
Which Should You Choose?
Human Growth Hormone (HGH) has stronger evidence for Fat Loss, Recovery & Healing. MK-677 (Ibutamoren) has stronger evidence for Sleep Quality.
Commonalities
Both Human Growth Hormone (HGH) and TB-500 are commonly used for Muscle Growth, Recovery & Healing.
Which Should You Choose?
Human Growth Hormone (HGH) has stronger evidence for Muscle Growth.
Commonalities
Both MK-677 (Ibutamoren) and TB-500 are commonly used for Muscle Growth, Recovery & Healing.
Which Should You Choose?
MK-677 (Ibutamoren) has stronger evidence for Muscle Growth. TB-500 has stronger evidence for Recovery & Healing.